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Speci?c phosphodiesterases such asPDE5 hydrolyze cGMP, thus regulating the intensity andduration of its vascular effects.
EPO is synthesizedby endothelial cells of the peritubular capillaries in therenal cortex and acts on specific receptors expressed onthe surface of erythrocyte progenitor (Er-P) cells in thebone marrow. Itis an autosomal recessive disorder caused by a mutation ina gene called the cystic fibrosis transmembrane con-ductance regulator (CFTR) located on chromosome 7.The product of this gene, the Cl~ channel protein, isinvolved in final alteration of mucus and digestive secre-tions, sweat, and tears.
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