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Macrophages that have phagocytosed cellular debris andinhaled environmental pollutants (e.g.,dust particles, silica, cigarette tar, andmicroorganisms) in the alveolar lumen migrate back to the alveolar septa,where they remain throughout life.These septal macrophages are seen hereaslarge, irregularly shaped cells loaded with black cytoplasmic inclusions thatobscure the view ofthe nucleus. Under anesthesia, respiratory characteristics such as effort and rate arevery important to monitor as well as SpO2, PaO2, and capnography.

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