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These pockets were dened by the original structure of a p53 peptidebound to MDM2, which showed three key residues of the p53 peptide, Phe19,Trp23, and Leu26, important for MDM2 binding. This model is used to determine the effective dose (eD) corresponding to a predetermined benchmarkresponse (BMR) (e.g. can you buy Keppra over the counter in uk 10% of the animals responding), which is termed the BMD. McGraw Hill, Inc., New YorkSassoon CS et al (1994) In?uence of pressure- and ? ow-triggered synchronous intermittent mandatory ventila-tion on inspiratory muscle work. These kinds of basic mod-els (although omitting inclusion of many other aging phe-notypes such as glycation, endocrine change, and telomereloss) (Figure 1.1) may provide a template for unravelingthe etiology of other neurodegenerative disorders, particu-larly AD, but also the FTD family and some types of cancer,where the connections to aging and aging phenotypes areless clearly established. The cells ofthe cumulus oophorus thatimmediately surround the oocyte and remain with it at ovula-tion are referred to as the corona radiata

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